Premature ejaculation sustinex extensil

Sustinex is a short-acting selective serotonin reuptake inhibitor for treatment of premature ejaculation (PE).

To evaluate the efficacy and safety of jaculation precoce oxetine (Extensil) 30 and 60 mg as needed in Asia-Pacific men with precoce ejaculation.


The study was a prospective, 12-week, open-label study to evaluate the efficacy and safety of flexible-dose precoce (dapoxetine) in men with PE diagnosed by a Premature Ejaculation Diagnostic Tool score of at least 11, a self-estimated intravaginal ejaculation latency time (IELT) no longer than 2 minutes, and an International Index of Erectile Function erectile function domain score of at least 21.

Main Outcome Measures

Percentage of subjects reporting their PE as at least “slightly better” using the Clinical Global Impression of Change (CGIC) question.


Two hundred eighteen of 285 randomized subjects completed the study. The mean subject age was 45.9 years and 57.7% were Korean. Dosages 1 (30 mg), 2 (30 → 60 mg), and 3 (30 → 60 → 30 mg) were used in 141, 124, and 13 subjects, respectively. At study end, a PE CGIC rating of at least “slightly better” was reported by 77.3%, 92.8%, and 100% of subjects for dosages 1, 2, and 3, respectively (P = .49). At study end, a CGIC rating of “slightly better” was reported by 85.2% and 85.3% of subjects with lifelong PE and acquired PE, respectively (P = .50).

At study end, a CGIC rating of “slightly better” was reported by 84.1% and 86.4% of subjects with an estimated baseline IELT no longer than and at least ≤1 minute, respectively (P = .16). The incidence of a CGIC rating of at least “slightly better” was lower in subjects reporting an adverse event of moderate or severe severity and in subjects who increased to and maintained a dapoxetine dose of 60 mg and higher in subjects older than 50 years and in subjects with a baseline estimated IELT of at least 1 minute.


In this study, flexible dosing of dapoxetine (30 and 60 mg) appeared effective in the treatment of precoce ejaculation.

5.0 rating
Cialis and generic tadalafil are equally effective
4.5 rating
Research shows that sildenafil helps the heart muscle relax properly, which could help patients with heart failure due to diastolic dysfunction
4.8 rating
Grapefruit can increase the chance of side effects with this medicine.